Fatty acid science articles

Interested in learning more about how oil for dogs works at a deeper, scientific level?
Dive into these scientific articles to learn more about dog nutrition and fatty acid science.
Our fatty acid science sources include following:

  • Oxford Journals
  • Wiley Online Library
  • Journal of the American Veterinary Medical Association
  • Springer Link
  • The International Journal of Applied Research in Veterinary Medicine
  • American Heart Association
  • US National Library of Medicine, National Institutes of Health

There are plenty more articles about fatty acid science and our experts will keep updating this site with new information.

Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model

“Our objective was to assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on atrial fibrillation (AF) vulnerability and atrial structure in a new model of atrial cardiomyopathy. Conclusion: n-3 PUFA supplementation can reduce AF vulnerability in a new canine pacing model of atrial cardiomyopathy. The mechanism may be related to attenuation of collagen turnover. “

Dose-Titration Effects of Fish Oil in Osteoarthritic Dogs

“Serum concentrations of EPA and DHA rose in parallel with food concentrations. For 2 of 5 clinical signs (lameness and weight bearing) and for overall arthritic condition and progression of arthritis, there was a significant improvement between the baseline and 3X EPA+DHA foods (P=.04, .03, .001, .0008, respectively) but not between the baseline and the 2X EPA+DHA foods. Conclusions and Clinical Importance: Increasing the amount of fish oil beyond that in the baseline food results in dose-dependent increases in serum EPA and DHA concentrations and modest improvements in the clinical signs of OA in pet dogs.”

Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis

“The change in mean peak vertical force between days 90 and 0 was significant for the test-food group (5.6%) but not for the control-food group (0.4%). Improvement in peak vertical force values was evident in 82% of the dogs in the test-food group, compared with 38% of the dogs in the control-food group. In addition, according to investigators’ subjective evaluations, dogs fed the test food had significant improvements in lameness and weight bearing on day 90, compared with measurements obtained on day 0. At least in the short term, dietary supplementation with fish oil omega-3 fatty acids resulted in an improvement in weight bearing in dogs with osteoarthritis.”

Early and Sustained Enrichment of Serum n-3 Long Chain Polyunsaturated Fatty Acids in Dogs Fed a Flaxseed Supplemented Diet

“Because conversion of DPAn-3 to DHA occurs in canine neurologic tissues, this DPAn-3 may provide a circulating reservoir for DHA synthesis in such tissues. The absence of DPAn-3 in serum-CE suggests that such transport may be unidirectional. Although conversion of DPAn-3 to DHA is slow in most species, one-way transport of DPAn-3 in the circulation may help conserve this fatty acid as a substrate for DHA synthesis in brain and retinal tissues especially when dietary intakes of DHA are low.”

Fish protein substrates can substitute effectively for poultry by-product meal when incorporated in high-quality senior dog diets

“Gene expression of cytokines tumour necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-10 and transforming growth factor (TGF)-β was determined by quantitative real-time polymerase chain reaction. Major compositional differences were noted among fish substrates but apparent nutrient digestibility coefficients and immune indices were not affected by treatment. Fish protein substrates were found to be effective substitutes for poultry by-product meal, providing diets of high nutritive value for senior dogs.”

Effects of weight loss on heart rate normalization and increase in spontaneous activity in moderately exercised overweight dogs

“Dogs preferentially lost fat mass, while maintaining and even increasing their lean tissues. The decrease in heart rate observed together with the increase in spontaneous physical activity measured after 12 weeks emphasize the need to propose both an adapted weight management diet and a daily activity during a weight loss program. The combination of diet and exercise will ensure a successful and healthy weight loss is reached and lean body condition is maintained long-term.”

Omega-3 fatty acid supplementation for the prevention of arrhythmias

“Fish oil, or omega-3 (n-3) polyunsaturated fatty acid (PUFA), supplements have been purported to produce potential health benefits. One of the strongest supported effects of n-3 PUFAs may be their potential benefits in reducing the risk of sudden cardiac death. This article reviews clinical and mechanistic studies that may explain the effects of these agents on ischemic arrhythmias, sudden death, and atrial fibrillation.”

Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

“With docosahexaenoic acid, 6 of 8 dogs were protected, and with α-linolenic acid, 6 of 8 dogs were also protected (P<0.004 for each). The before and after control studies performed on the same animal all resulted in fatal ventricular arrhythmias, from which they were defibrillated. These results indicate that purified ω-3 fatty acids can prevent ischemia-induced ventricular fibrillation in this dog model of sudden cardiac death.”

Effect of an omega-3/omega-6 fatty acid-containing commercial lamb and rice diet on pruritus in atopic dogs: results of a single-blinded study.

“Plasma and skin levels of examined fatty acids changed in all 18 dogs when their diet was switched to the test diet. Dogs responding to the test diet had a different pattern of fatty acid change as compared to the dogs which failed to respond to the diet, suggesting that there are subsets of atopic dogs with different fatty acid metabolism capabilities.”

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